Chrisochlorys Ameghino, 1884 accepted as Chrysochloris Lacepède, 1799 (original description)
Cologenyx Ameghino, 1884 † accepted as Cuniculus Brisson, 1762 (original description)
Essonodontherium Ameghino, 1884 † accepted as Megatherium Cuvier, 1796 † (original description)
Gliptodon Ameghino, 1884 † accepted as Glyptodon Owen in Parish, 1838 † (original description)
Hyaemoschus Ameghino, 1884 accepted as Hyemoschus Gray, 1845 (original description)
Hyoemoschus Ameghino, 1884 accepted as Hyemoschus Gray, 1845 (original description)
Melex Ameghino, 1884 accepted as Meles Brisson, 1762 (original description)
Metasimia Ameghino, 1884 † (original description)
Oligotherium Ameghino, 1884 † (original description)
Panochtus Ameghino, 1884 † accepted as Panochthus Burmeister, 1866 † (original description)
Plioganphiodon Ameghino, 1884 † (original description)
Protelex Ameghino, 1884 accepted as Proteles Geoffroy, 1824 (original description)
Prothomo Ameghino, 1884 † (original description)
Prothylobates Ameghino, 1884 † (original description)
Protosimia Ameghino, 1884 † (original description)
Protroglodytes Ameghino, 1884 † (original description)
Ptermoys Ameghino, 1884 accepted as Pteromys Cuvier, 1800 (original description)
Tetraprothomo Ameghino, 1884 † accepted as Cyonasua Ameghino, 1885 † (original description)
Triprothomo Ameghino, 1884 † (original description)
Triprotosimia Ameghino, 1884 † (original description)
Triprotroglodytes Ameghino, 1884 † (original description)